John Philip Chang

  • Adjunct Professor

Research Interests

Signal transduction mechanisms integrating the neuroendocrine regulation of vertebrate pituitary hormone release, especially in fishes.
Neuroendocrine regulation of reproduction and growth.
Evolution of receptors and post-receptor mechanisms of hypothalamic neuropeptides and bioamines, particularly GnRH peptides, PACAP, somatostatins, Ghrelin, serotonin, dopamine and norepinephrine.

Selected Publications

  • Canosa, L.F., Chang, J.P., Peter, R.E. 2007. Neuroendocrine control of growth hormone in fish.  General and Comparative Endocrinology. 151: 1-26.
  • Martyniuk, C.J., Chang, J.P., and Trudeau, V.L. 2007.  The effects of GABA agonists on GAD, GABA-T, activin, sGnRH, and tyrosine hydroxylase mRNA in the goldfish (Carassius auratus) neuroendocrine brain. J Neuroendocrinology. 19: 390-397.
  • Hontela, A., Leblond, V.S., Chang, J.P. 2008. Purification and isolation of corticosteroidogenic cells from head kidney of rainbow trout (Oncorhynchus mykiss) for testing cell-specific effects of a pesticide. Comparative Biochemistry and Physiology – Part C: Toxicology & Pharmacology. 147: 52-60.
  • Mitchell, G., Sawisky, G.R., Grey, C.L., Wong, C.J, Uretsky, A.D., Chang, J.P.  2008. Differential involvement of nitric oxide signaling in dopamine and PACAP stimulation of growth hormone release in goldfish.  Gen. Comp. Endocrinol. 155: 318-327. 
  • Klausen, C., Booth, M., Habibi, H.R., Chang, J.P.  2008. Extracellular signal-regulated kinase mediates gonadotropin subunit gene expression and LH release responses to endogenous gonadotropin-releasing hormones in goldfish.  Gen. Comp. Endocrinol. 158: 36-46.
  • Yu, Y., Wong, A.O.L., and Chang, J.P. 2008. Serotonin interferes with Ca2+ and PKC signaling to reduce gonadotropin-releasing hormone-stimulated GH secretion in goldfish pituitary cells.  General and Comparative Endocrinology 159: 58-66.
  • Grey, C.L., and Chang, J.P. 2009.  Ghrelin-induced growth hormone release from goldfish pituitary cells involves voltage-gated calcium channels. Gen. Comp. Endocrinol. 160: 148-157.
  • Chang, J.P., Johnson, J.D., Sawisky, G.R., Grey, C.L., Mitchell, G., Booth, M., Volk, M.M., Parks, S.K., Thompson, E., Goss, G.G., Klausen, C., and Habibi, H.R.  2009.  Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts – studies on the goldfish model. Gen. Comp. Endocrinol. 161: 42-52. 
  • Zhao, E., Basak, A., Wong A.O.L., Ko, W., Chen, A., López, G.C., Grey, C.L., Canosa, L.F., Somoza, G.M., Chang, J.P., Trudeau, V.L.  2009.  The secretogranin II-derived peptide secretoneurin stimulates luteinizing hormone secretion from gonadotrophs.  Endocrinology (accepted Dec 10, 2008; doi:10.1210/en.2008-1060).
  • Cao, Y.B., Chen, X.Q., Wang, S., Chen, X.Z., Wang, Y.X., Chang, J.P., Du, J-Z.  2009.  Growth hormone and insulin-like growth factor of naked carp (Gymnocypris przewalskii) in Lake Qinghai: expression in different water environments.  General and Comparative Endocrinology (accepted Feb 9, 2009; doi: 10.1016/j.ygcen.2009.02.005)
Photograph of John Philip Chang


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