University of Calgary
Alexander de Leon
- Associate Professor
- Statistics and Actuarial Science
- +1 (403) 220-6782
Website:
Research Group in Biostatistics (RGB)
I belong to the Research Group in Biostatistics (RGB), a group of statisticians and biostatisticians in the Department of Mathematics and Statistics who carry out methodological research in statistics with emphasis on its applications in medicine and health, biology, genetics, the environment, and other related fields.
I am also a member of the University of Calgary Biostatistics Centre (UCBC), a multi-faculty initiative “housed” in the O’Brien Institute for Public Health in the Cumming School of Medicine. The UCBC administers the interdisciplinary specializations in Biostatistics of the MSc-thesis and PhD joint programs of the Departments of Community Health Sciences and Mathematics and Statistics.
Office Hours
| Monday | Tuesday | Wednesday | Thursday | Friday | Saturday | Sunday |
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| - | 1p‑2p | - | 1p‑2p | - | - | - |
Research Interests
Currently Teaching
| W2024 - DATA 606 - Statistical Methods in Data Science | |||||||||||||||||
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| W2024 - STAT 517 - Practice of Statistics | |||||||||||||||||
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| F2024 - STAT 421 - Mathematical Statistics | |||||||||||||||||
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| F2024 - STAT 525 - Applied Multivariate Analysis | |||||||||||||||||
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| F2024 - STAT 625 - Multivariate Analysis | |||||||||||||||||
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| W2025 - STAT 431 - Introduction to Biostatistics | |||||||||||||||||
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Graduate Students
Meijie Guo (M.Sc., 2003-2005), Yongtao Zhu (M.Sc., 2004-2006), Yifan Zhu (M.Sc., 2008-2010; co-supervised with Hyang-Mi Kim), Fatemeh Jiryaie (Visiting Ph.D. student, May-October 2012), Yamuni Perera (M.Sc., 2011-2013), Beilei Wu (Ph.D., 2009-2013; M.Sc., 2007-2009), Niroshan Withanage (Ph.D., 2009-2013), Xiaoran Xie (M.Sc., 2012-2014; co-supervised with Jingjing Wu), Ji Ruan (M.Sc., 2013-2015), Fahmida Yeasmin (M.Sc., 2013-2015), Mili Roy (M.Sc., 2013-2015), Hatice Akdur (Visiting Ph.D. student, August-December 2015), Mingchen Ren (M.Sc., 2014-2016; co-supervised with Ying Yan), Saifa Raz (M.Sc., 2014-2016; co-supervised with Jingjing Wu), Katherine Burak (2019, o-supervised with Jingjing Wu), Ajmery Jaman (2019, o-supervised with Jingjing Wu), Joyce Raymond Punzalan (Visiting Ph.D. student, May-December 2019)
Undergraduate Research Students
Gurbakhshash Singh (Summer 2003), Andrea Soo (Summer 2006), Jan Owoc (Fall 2008), Yamuni Perera (Summer 2009), Danny Lu (Summer 2014; co-supervised with Karen Kopciuk), Dylan Loader (2017)
Editorial Service
Associate Editor, Journal of Statistical Computation & Simulation
Research Collaborators
K Carriere Chough (University of Alberta), CJ Rudnisky (University of Alberta), N Withanage (University of Sri Jayewardenepura), B Wu (PAREXEL), M Ghahramani (University of Winnipeg), O Dag (Hacettepe University), D Bonzo (PAREXEL), A Jamalizadeh (Shahid Bahonar University), K Zografos (University of Ioannina), M Jaffa (American University of Beirut), JB Punzalan (University of the Philippines), O Ilk-Dag (Middle East Technical University), Z Kalaylioglu (Middle East Technical University), R Kurada (SAS), G Inan (Middle East Technical University), A Soo (University of Calgary), F Jiryaie (Shahid Beheshti University)
Publications
Book Chapter
- de Leon, Alexander and Carriere Chough, K. "Analysis of mixed data: An overview" In Analysis of Mixed Data: Methods & Applications Chapman & Hall/CRC Press, 2013. 1-11. Print.
- Wu, Beilei, de Leon, Alexander and Withange, Niroshan. "Joint analysis of mixed discrete and continuous outcomes via copulas" In Analysis of Mixed Data: Methods & Applications Chapman & Hall/CRC Press, 2013. 139-156. Print.
- de Leon, Alexander and Carriere Chough, K. "Mixed-outcome data" Encyclopedia of Biopharmaceutical Statistics (3rd ed) Informa Healthcare, 2010. 817-822. Print.
Book Review
- de Leon, Alexander. Review of “Latent Markov Models for Longitudinal Data,” by F. Bartolucci, A. Farcomeni & F. Pennoni Technometrics, 2014. 57.1, 139. Print.
Edited Book
- de Leon, Alexander and Carriere Chough, K (eds). Analysis of Mixed Data: Methods & Applications Chapman & Hall/CRC Press, 2013. 262 pp. Print.
Journal Article
- Perera, Y, Ren, Mingchen, Punzalan, JB, Rudnisky, CJ and de Leon, Alexander. "Binocular sensitivity and specificity of screening tests in cross-sectional diagnostic studies of paired organs". Statistics in Medicine, 36.11 (2017): 1754-1766. Print.
- Lu, D, Weljie, A, de Leon, Alexander, McConnell, Y, Bathe, OF and Kopciuk, Karen. "Performance of variable selection methods using stability-based selection". BMC Research Notes 10.143 (2017). Print.
- Jiryaie, F, Withanage, N, Wu, B and de Leon, Alexander. "Gaussian copula distributions for mixed data, with application in discrimination". Journal of Statistical Computation & Simulation 86.9 (2016): 1643-1659. Print.
- Withanage, N, de Leon, Alexander and Rudnisky, CJ. "Joint estimation of multiple disease-specific sensitivities and specificities via crossed random effects models for correlated reader-based diagnostic data: Application of data cloning". Statistics in Medicine 34.29 (2015): 3916-3928. Print.
- Wu, Beilei and de Leon, Alexander. "Gaussian copula mixed models for clustered mixed outcomes, with application in developmental toxicology". Journal of Agricultural, Biological and Environmental Statistics 19.1 (2014): 39-56. Print.
- Inan, G, Ilk-Dag, O and de Leon, Alexander. "Letter to the Editor re: "Logistic regression with multiple random effects: A simulation study of estimation methods and statistical packages," by Y. Kim, Y.-K. Choi, & S. Emery". American Statistician 68.2 (2014): 129-130. Print.
- Withanage, N, de Leon, Alexander and Rudnisky, CJ. "Joint estimation of disease-specific sensitivities and specificities in reader-based multi-disease diagnostic studies of paired organs". Journal of Applied Statistics 41.10 (2014): 2282-2297. Print.
- de Leon, Alexander, Mahmoodian, H and Jamalizadeh, A. "Distributional results for L-statistics based on random vectors with multivariate elliptical distributions". Chilean Journal of Statistics 4.1 (2013): 69-85. Print.
- de Leon, Alexander and Punzalan, J. "An elementary proof of independence of least squares estimators of regression coefficients and of variance in linear regression". Philippine Statistician 62.1 (2013): 77-81. Print.
- Wu, B and de Leon, Alexander. "Letter to the Editor re: "Sample size determination in clinical trials with multiple co-primary endpoints including mixed continuous and binary variables," by T. Sozu, T. Sugimoto, & T. Hamasaki". Biometrical Journal 55.5 (2013): 807-812. Print.
- de Leon, Alexander and Wu, Beilei. "Copula-based regression models for a bivariate mixed discrete and continuous outcome". Statistics in Medicine 30.2 (2011): 175-185. Print.
- de Leon, Alexander, Soo, A and Williamson, T. "Classification with discrete and continuous variables via general mixed-data models". Journal of Applied Statistics 38.5 (2011): 1021-1032. Print.
- de Leon, Alexander, Soo, A, Bonzo, D and Rudnisky, C. "Joint estimation of diagnostic accuracy measures for paired organs-Application in ophthalmology". Biometrical Journal 51.5 (2009): 837-850. Print.
- de Leon, Alexander and Zhu, Y. "ANOVA extensions for mixed discrete and continuous data". Computational Statistics & Data Analysis 52.4 (2008): 2218-2227. Print.
- de Leon, Alexander. "One-sample likelihood ratio tests for mixed data". Communications in Statistics. A. Theory and Methods 36.1 (2007): 129-141. Print.
- de Leon, Alexander, Guo, M, Rudnisky, CJ and Singh, G. "A likelihood approach to estimating sensitivity and specificity for binocular diagnostic data: Application in ophthalmology". Statistics in Medicine 26.17 (2007): 3300-3314. Print.
- de Leon, Alexander and Carriere, KC. "General mixed-data model: Extension of general location and grouped continuous models". Canadian Journal of Statistics 35.4 (2007): 533-548. Print.
- Rudnisky, CJ, Tennant, M, de Leon, Alexander, Hinz, B and Greve, M. "Benefits of stereopsis when identifying clinically significant macular edema via teleophthalmology". Canadian Journal of Ophthalmology 41.6 (2006): 727-732. Print.
- de Leon, Alexander and Carriere, KC. "A generalized Mahalanobis distance for mixed data". Journal of Multivariate Analysis 92.1 (2005): 174-185. Print.
- de Leon, Alexander. "Pairwise likelihood approach to grouped continuous model and its extension". Statistics and Probability Letters 75.1 (2005): 49-57. Print.
- Somani, R, Tennant, M, Rudnisky, CJ, Weis, E, Ting, A, Greve, M, Hinz, B and de Leon, Alexander. "Comparison of stereoscopic digital imaging to film in the identification of macular degeneration". Canadian Journal of Ophthalmology 40.3 (2005): 293-302. Print.
- Baker, C, Rudnisky, CJ, Tennant, M, Sanghera, P, Hinz, B, de Leon, Alexander and Greve, M. "JPEG compression of stereoscopic digital images for diagnosis of diabetic retinopathy via tele-ophthalmology". Canadian Journal of Ophthalmology 39.7 (2004): 746-754. Print.
- Rudnisky, CJ, Hinz, B, Tennant, M, de Leon, Alexander and Greve, M. "High-resolution stereoscopic digital fundus photography versus contact-lens biomicroscopy for the detection of clinically significant macular edema". Ophthalmology 109.2 (2002): 267-274. Print.
- de Leon, Alexander and Carriere, KC. "On the one-sample location hypothesis for mixed bivariate data". Communications in Statistics. A. Theory and Methods 29.11 (2000): 2573-2581. Print.
Other
- Torabi, M and de Leon, Alexander. Conditional dependence in mixed models for a non-Gaussian longitudinal outcome 2017.
- Wu, B, Inan, G and de Leon, Alexander. Joint analysis of correlated mixed data via Gaussian copula models with jittered binary outcomes 2016.
- Ruan, Ji, Zhang, J and de Leon, Alexander. Impact of misspecified dependence on clustering of RNA-seq gene expression profiles 2016.
- Ghahramani, Melody, Dag, Osman and de Leon, Alexander. Analysis of autocorrelated count data: A combined estimating function approach 2016.
- Withange, Niroshan, Roy, M, Geys, H, Van der Leede, BJ and de Leon, Alexander. Conditional dependence in joint analysis of correlated non-Gaussian continuous outcomes 2014.
- Wu, B, Akdur, H, Bonzo, Daniel and de Leon, Alexander. Sample size calculation in clinical trials with mixed binary and continuous co-primary endpoints: Application of Gaussian copula models 2014.
- Wu, B, Roy, M and de Leon, Alexander. Joint analysis of multiple longitudinal mixed outcomes via Gaussian copula mixed models 2013.
- de Leon, Alexander, Wu, Beilei and Punzalan, JB. Comparison of regression lines based on individual and averaged data 2010.
Degrees
- PhD - Statistics
University of Alberta
Awards
- 2015 - GREAT Supervisor Award - Faculty of Graduate Studies
- 2012 - NSERC - unclassified
Students
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