University of Calgary

Sergei Noskov

  • Professor
  • Associate Head - Research
  • Biochemistry

Research Interests

Molecular Modelling, Membrane Proteins (Ion Channels and Ion-coupled
transporters), Quantum Chemistry of Biologically Relevant Molecules, Free
Energy Profiles, Protein Structure/Function prediction


2005 - Paper on K+ channel scored 9.6 (Rated: Exceptional) at the Faculty1000 system
2004 - American Epilepsy Foundation Fellowship (WMC of Cornell University)
2002 - INTAS (European Union) Award for Young Scientist (KTH, Stockholm)
1997 - OeAD Research Scholarship (Austria, University of Innsbruck)

Selected Publications

  • Google Scholar Link
  • Noskov S.Y., Roux B. 2006, Importance of Hydration and Dynamics on the Selectivity of the KcsA and NaK Channels, Journal of General Physiology, In press
  • Noskov S.Y., Lamoureux G., Roux B. 2005 Microscopic picture of hydrophobic hydration in water-ethanol mixtures from simulation with new polarizable force-field“. Journal of Physical Chemistry B, 109, 6705-6713
  • Noskov SY, Berneche S, Roux, B 2004 Control of ion selectivity in potassium channels by electrostatic and dynamic properties of coordinating ligands. Nature, vol. 431, 830-834
  • Noskov SY, Im W, Roux B. 2004 Ion Permeation through the alpha-hemolysin Channel: Theoretical Studies Based on Brownian Dynamics and Poisson-Nernst-Plank Electrodiffusion Theory. Biophysical. Journal., 87, 2299-2309
  • Noskov SY, Wright JD, Lim C., 2002 Long-Range Effects of Mutating R248 to
    Q/W in the p53 Core Domain Journal of Physical. Chemistry B, 2002, 106;
  • Wright J.D., Noskov S.Y., Lim C. 2002 Factors governing loss and rescue of DNA binding upon single and double mutations at P53 core domain. Nucleic Acids Research , 30; 1563-1574
  • Noskov S.Y., Lim C. 2001 Free energy decomposition of protein-protein interaction. Biophysical Journal., 81;737-750


  • PhD
    Russian Academy of Sciences, 1999
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