University of Calgary

Elmar Josef Prenner

  • Associate Professor
  • Associate Head - Research & Plannin
  • Biochemistry

Research Interests

Biomembrane architecture (lipid rafts, domains), lipid-protein interactions, antimicrobial peptides; nanoparticle based pulmonary drug delivery; bioinorganic chemistry (membrane interactions of heavy metals); bioanalytical chemistry (bioassay development), biophysical techniques.

High throughput screening of biosurfactants [Hydrocarbon Metagenomics project]

 

Graduate Students

Lai, Patrick Ph.D. Nanoparticle based pulmonary drug delivery
Mahadeo, Mark  Ph.D. Impact of lipid based anticancer drugs on membrane architecture
Patterson, Matthew M.Sc. Lipid-protein interactions in tear film model systems
Weiam Daear  MSc Nanoparticle synthesis and characterization
Evan Kerek  MSc

Membrane interactions of toxic metals

     
Chiu, Michael MD-MSc Membrane interactions of antimicrobial peptides

Awards

2006 - Poster prize by the Petroleum Tech Alliance of Canada for the 'most innovative water-related technology'
2002 - AHFMR Scholar award grant

 

Selected Publications

  • Google Scholar Link
  • T. Abraham, E.J. Prenner, R.N.A.H. Lewis, C.T. Manz, R.S. Hodges and R.N. McElhaney Structure-Activity Relationships of the Antimicrobial Peptide Gramicidin S and its Analogues: Aqueous Solubility, Self Association, Conformation, Antimicrobial Activity and Interaction with  Lipid Bilayer Model Membranes Biochim. Biophys. Acta 1838 (2014) 1420-142 
  • M.T. Le, M. Hassanin, M. Mahadeo, J. Gailer, E.J. Prenner Hg- and Cd-induced modulation of lipid packing and monolayer fluidity in biomimetic erythrocyte model systems. Chemistry and Physics of Lipids 170– 171 (2013) 46– 54 
  • S. Nathoo, J.K. Litzenberger, D. Bay, R.J. Turner, and E.J. Prenner* Visualizing a multidrug resistance protein, EmrE, with major bacterial lipids using Brewster angle microscopy Chem Phys Lipids 167– 168 (2013) 33– 42 
  • T. Gröger, S. Nathoo, T. Ku, C. Sikora, R. J. Turner and E. J. Prenner* Real-time imaging of lipid domains and distinct coexisting membrane protein clusters Chem. Phys. Lipids 165 (2012) 216-224 
  • M. H. Chiu and E. J. Prenner* Differential scanning calorimetry: an invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. J. Pharm. BioAllied Sciences 3 (2011) 39-59 (invited review)
  • S. Nathoo, J.K. Litzenberger, D. Bay, R.J. Turner, and E.J. Prenner Visualizing a multidrug resistance protein, EmrE, with major bacterial lipids using Brewster angle microscopy Chem Phys Lipids 167– 168 (2013) 33– 42 
  • T. Gröger, S. Nathoo, T. Ku, C. Sikora, R. J. Turner and E. J. Prenner* Real-time imaging of lipid domains and distinct coexisting membrane protein clusters Chem. Phys. Lipids 165 (2012) 216-224 
  • M. H. Chiu and E. J. Prenner* Differential scanning calorimetry: an invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions. J. Pharm. BioAllied Sciences 3 (2011) 39-59 (invited review) 
  • P. Lai, S. Nathoo, T. Ku, S. Gill, S. Azarmi, W. Roa, R. Löbenberg and E.J. Prenner. Real-time imaging of interactions between dipalmitoylphosphatidylcholine monolayers and gelatin based nanoparticles using Brewster Angle Microscopy. J Biol Nanotech 6 (2010), 1-8 
  • E. F. Haney, S. Nathoo, H. J. Vogel and E. J. Prenner. Induction of non-lamellar lipid phases by antimicrobial peptides: A possible link to mode of action? Chem. Phys. Lipids 163 (2010) 82–93
  • M. H Chiu, C.-P. L. Wan, P. M.M. Weers and E. J. Prenner. Apolipophorin III Interaction with Model Membranes Composed of Phosphatidylcholine and Sphingomyelin using Differential Scanning Calorimetry Biochim. Biophys Acta 1788 (2009) 2160–2168
  • M.T. Le, J. Gailer and E. J. Prenner. Hg++ and Cd++ interact differently with biomimetic erythrocyte membranes Biometals 22 (2009) 261-274
  • T. Ku, S. Gill, R. Löbenberg, S. Azarmi, W. Roa and E. J. Prenner. Size Dependent Interactions of Nanoparticles with Lung Surfactant Model Systems and the Significant Impact on Surface Potential. J Nanosci Nanotech 8 (2008) 2971-2978
  • V.V. Andrushchenko, M.H. Aarabi, L.T. Nguyen, E.J. Prenner and H.J. Vogel. Thermodynamics of the Interactions of Tryptophan-Rich Cathelicidin Antimicrobial Peptides with Model and Natural Membranes Biochim. Biophys. Acta 1778 (2008) 1004-1014
  • V.V. Andrushchenko, H.J. Vogel and E.J. Prenner. Interactions of Tryptophan-Rich Cathelicidin Antimicrobial Peptides with Model Membranes Studied by Differential Scanning Calorimetry. Biochim. Biophys. Acta 1768 (2007) 2447-2458
  • S. Gill, R. Loebenberg, T. Ku, S. Arzami, W. Roa and E. J. Prenner. Nanoparticles: Characteristics, Mechanisms of Action and Toxicity in Pulmonary Drug Delivery-A Review. J Biomed Nanotech. 2 (2007) 107-119
  • E.J. Prenner, G. Honsek, D. Hönig, D. Möbius and K. Lohner. Biophysical investigations and imaging of the lateral organization of sphingomyelin and phosphatidylcholine monolayers. Chem. Phys. Lipids 145 (2007) 106-118

Degrees

  • PhD - Technical Chemistry
    University of Technology Graz, 1993
  • Dipl-Ing - Technical Chemistry
    University of Technology Graz, 1988
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